Definition
Semaglutide is a synthetic GLP-1 receptor agonist analog, CAS 910463-68-2. Approved medicines exist in this class (for example branded GLP-1 medicines). Research reagents are not interchangeable with those products and are not for weight-loss consumer use.
PubChem: Semaglutide
Key Facts
- Compound: Semaglutide (GLP-1 analog)
- CAS: 910463-68-2
- Size: 5 mg
- Purity: ≥99% HPLC; batch COA
- Use: Laboratory research only
Last reviewed: 2026-10-15
Key Characteristics
MOLECULAR PROFILE
Formula: C187H291N45O59
Weight: ~4113.6 g/mol
CAS: 910463-68-2
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Soluble in bacteriostatic water or sterile lab-grade water
Stability: Stable when stored dry, cold, and protected from light
Storage: -20°C preferred (lyophilized); 2-8°C after reconstitution
Mechanism of Action (Research Context)
Semaglutide is studied as a long-acting GLP-1 receptor agonist analog in signaling assays and comparative incretin pharmacology. Drug-product findings do not authorize human use of research chemicals.
Class Comparison: Semaglutide vs Tirzepatide vs Retatrutide
| Feature | Semaglutide (class) | Tirzepatide (class) | Retatrutide |
|---|---|---|---|
| Agonist type | Single (GLP-1) | Dual (GLP-1 + GIP) | Triple (GLP-1 + GIP + glucagon) |
| Primary research focus | Appetite and glucose pathways | Dual incretin pathways | Incretin plus glucagon and energy-expenditure pathways |
| Regulatory note | Approved medicines exist in this class. Research reagents are not medicines. | Approved medicines exist in this class. Research reagents are not medicines. | Investigational. Not FDA-approved. Research supply is not a medicine. |
Scientific orientation only. Prescription medicines and research reagents are not interchangeable.
Research Applications
- GLP-1 receptor pharmacology
- Comparative single- versus dual- versus triple-agonist research designs
- Analytical identity methods
Laboratory Notes
High-level handling notes for Semaglutide. Detailed reconstitution steps live on the product page. Always defer to your lab SOP and batch COA.
Scientific References
- Lau J, et al. Discovery of semaglutide. J Med Chem. 2015.
- PubChem. Semaglutide.
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Buy research-grade Semaglutide from Osae Research (sizes, COA, shipping).
Legal Disclaimer
Content is for scientific orientation. Materials from Osae Research are for laboratory research only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.