Definition
Tirzepatide is a synthetic dual agonist of GLP-1 and GIP receptors, identified as LY3298176 (CAS 2023788-19-2). Literature describes fatty-acid acylation supporting albumin binding.
Approved medicines exist in this pharmacological class. Osae Research materials are laboratory reagents only, not interchangeable with prescription products.
PubChem: Tirzepatide
Key Facts
- Compound: Tirzepatide (LY3298176)
- CAS: 2023788-19-2
- Purity: ≥99% HPLC; batch COA
- Sizes: 10 mg, 30 mg
- Use: Laboratory research only
Last reviewed: 2026-10-15
Key Characteristics
MOLECULAR PROFILE
Formula: C225H348N48O68
Weight: ~4813 g/mol
CAS: 2023788-19-2
Synonyms: Tirzepatide; LY3298176
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Soluble in bacteriostatic water or sterile lab-grade water
Stability: Stable when stored dry, cold, and protected from light
Storage: -20°C preferred (lyophilized); 2-8°C after reconstitution
Mechanism of Action (Research Context)
Tirzepatide is studied as a dual incretin receptor agonist. Researchers compare dual GLP-1/GIP engagement with single GLP-1 agonists in signaling assays and metabolic-marker models. Clinical drug findings do not authorize human use of research chemicals.
Class Comparison: Semaglutide vs Tirzepatide vs Retatrutide
| Feature | Semaglutide (class) | Tirzepatide (class) | Retatrutide |
|---|---|---|---|
| Agonist type | Single (GLP-1) | Dual (GLP-1 + GIP) | Triple (GLP-1 + GIP + glucagon) |
| Primary research focus | Appetite and glucose pathways | Dual incretin pathways | Incretin plus glucagon and energy-expenditure pathways |
| Regulatory note | Approved medicines exist in this class. Research reagents are not medicines. | Approved medicines exist in this class. Research reagents are not medicines. | Investigational. Not FDA-approved. Research supply is not a medicine. |
Scientific orientation only. Prescription medicines and research reagents are not interchangeable.
Research Applications
- Incretin receptor pharmacology
- Comparative dual- versus single-agonist experiments
- Analytical method development
Laboratory Notes
High-level handling notes for Tirzepatide. Detailed reconstitution steps live on the product page. Always defer to your lab SOP and batch COA.
Scientific References
- Coskun T, et al. LY3298176 dual GIP/GLP-1 agonist. Mol Metab. 2018.
- Jastreboff AM, et al. Tirzepatide once weekly for obesity. N Engl J Med. 2022.
- PubChem. Tirzepatide.
Buy Research-Grade Material
Buy research-grade Tirzepatide from Osae Research (sizes, COA, shipping).
Legal Disclaimer
Content is for scientific orientation. Materials from Osae Research are for laboratory research only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.